The major objective of this research is to investigate how the new economics of skilled labor migration focusing on medical doctors can provide new economic and policy avenues that can strengthen the collaboration between Northern and Southern economies. Most of the attention is devoted to the European countries with their links to ECE and MENA. The most important motivation of this investigation resides in finding out whether there are possible and feasible economic and social policies that can transform the brain-drain debate into win-win avenues of further collaboration. As the international set-up has already launched the global health system, new skilled labor migration policies as implied by the new economics of skilled labor as applied to medical doctors might generate new conditions for health gains in both Europe, ECE and MENA countries. This can be expanded to other world regions as promised by the global health system.The realization of this objective is achieved through series of methods that emphasize both the description of past and current situations and the analysis of the determinants of migration.